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Journal of Traditional Chinese Medicine ›› 2020, Vol. 40 ›› Issue (2): 311-316.DOI: 10.19852/j.cnki.jtcm.2020.02.015

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Transforming growth factor β1 is a differentially expressed candidate protein of congestive heart failure with Qi-deficiency-blood-stasis syndrome

Li Xiaoqian, Huang Pinxian, Wang Shijun, Cao Xuebin, He Jiancheng   

  1. Research Centre on Application of Classical Prescriptions, Basic Medical College, Shanghai University of Traditional Chinese Medicine;Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University;Department of Cardiology, The PLA 252 Hospital;
  • Online:2020-04-15 Published:2020-04-15
  • Supported by:
    Supported by the Natural Science Foundation of China (No.81803996), the Major Clinical Research Project of the Army(No. 2006021003), the Training Plan on Excellent Academic Leader of Shanghai Health System (No. XBR2011070), Construction of Clinical Basic Discipline of TCM (No. A1-Z183020110)

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Abstract: OBJECTIVE: To investigate the role of tongue coating fluid protein in regulation of congestive heart failure(CHF) in Qi-deficiency-blood-stasis syndrome.METHODS: We studied patients with CHF(3 patients with Qi-deficiency-blood-stasis syndrome and 3 without Qi-deficiency-blood-stasis syndrome) to investigate differentially expressed proteins. We also included a control group. A biotin label-based antibody array was used for testing tongue coating fluid samples from patients. Net-work analysis of these differentially expressed proteins was conducted using the STRING database,which can predict the relations between differentially expressed proteins and CHF with Qi-deficiency-blood-stasis syndrome.RESULTS: A total of seven differentially expressed proteins were identified, and among these, transforming growth factor β1(TGF-β1) gets a particular attention for us has drawn specific attention.Network analysis showed a homologous relationship of TGF-β1 with bone morphogenetic protein15, which is associated with myocardial fibrosis.CONCLUSION: Occurrence and development of CHF may result from certain DE-proteins and associated signaling pathways. TGF-β1 protein may be a candidate marker for assessing the risk of CHF in Qideficiency-blood-stasis syndrome.

Key words: Congestive heart failure, Qi-deficiency blood-stasis, Transforming growth factor β1, Bone morphogenetic protein 15, Differentially expressed protein

Cite this article

Li Xiaoqian, Huang Pinxian, Wang Shijun, Cao Xuebin, He Jiancheng. Transforming growth factor β1 is a differentially expressed candidate protein of congestive heart failure with Qi-deficiency-blood-stasis syndrome[J]. Journal of Traditional Chinese Medicine, 2020, 40(2): 311-316.