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Journal of Traditional Chinese Medicine ›› 2020, Vol. 40 ›› Issue (2): 212-223.DOI: 10.19852/j.cnki.jtcm.2020.02.005

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Effects of modified Wenjing decoction on microcirculation in reproductive organs in rats with symptom patterns of cold coagulation and blood stasis

Wang Di, Cheng Xiumei, Fang Huimin, Ren Yanqing, Li Xinhua, Ren Weiwei, Xue Bing, Yang Cairui   

  1. Department of Acupuncture and Massage, Hebei University of Chinese Medicine;Department ofintegrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine;Department of Basic Medicine, Hebei University of Chinese Medicine;Department of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine;Department of Medicine, Hebei University of Chinese Medicine;
  • Online:2020-04-15 Published:2020-04-15
  • Supported by:
    Supported by Natural Science Foundation-funded Project Based on the Theory of "Cold Leads to Blood Vessel Collection and Blood Stasis",to Discuss the Characteristics of Microvascular Endothelial Function Changes in the Syndrome of Cold Coagulation and Blood Stasis,and the Influence of TCM (No. 81373514)

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Abstract: OBJECTIVE: To investigate the relationship between symptom patterns of cold coagulation and blood stasis(CCBS) and microcirculation disturbance. In addition, we determined the efficacy of modified Wenjing decoction(WJD) for the treatment of CCBS.METHODS: CCBS was induced in rats with an icewater bath treatment. The ovarian function, microvascular and circulatory status of reproductive organs, and function of local microvascular endothelial cells(VECs) and vascular smooth muscle cells(VSMCs) were evaluated.RESULTS: Ovarian dysfunction was observed in the rats with CCBS. It was characterized by the presence of an estrous cycle disorder and a decrease in reproductive hormone levels. Microvascular circulation disorders were associated with an imbalance in vasoconstriction, relaxation substances, nitric oxide, abnormal blood flow in whole blood, and decreased blood flow in the auricle and uterus. VECs were damaged, and VSMCs contracted and proliferated in ovarian and uterine tissues.CONCLUSION: Our findings suggest that the dysfunctional reproductive organs observed in gynecological CCBS may be closely related to the microcirculation disturbance of local tissues, microvascular contraction, and vascular remodeling. Modified WJD can be used to treat CCBS by improving microcirculation in reproductive organs.

Key words: Cold stress, Reproduction organs, Microcirculatory, Modified Wenjing decoction

Cite this article

Wang Di, Cheng Xiumei, Fang Huimin, Ren Yanqing, Li Xinhua, Ren Weiwei, Xue Bing, Yang Cairui. Effects of modified Wenjing decoction on microcirculation in reproductive organs in rats with symptom patterns of cold coagulation and blood stasis[J]. Journal of Traditional Chinese Medicine, 2020, 40(2): 212-223.