Abstract: OBJECTIVE: To evaluated the effectiveness and safety of Chinese herbal medicines(CHMs) for coronary heart disease(CHD) complicated with anxiety.METHODS: Randomized controlled clinical trials(RCTs) with parallel-groups were included after searching through electric-databases from inception to May, 2017. Meta-analysis was undertaken with Rev Man 5.3 software.RESULTS: Twenty-three RCTs enrolling 1654 patients were included in this systematic review. The combination therapy(CHMs combined with anxiolytic) appeared to be superior to anxiolytic in terms of reducing the score of Zung Self-rating Anxiety scale(SAS)(mean Difference(MD),-12.25; 95%confidence interval(CI),-14.01 to-10.48, eliminating method; MD,-3.92; 95% CI,-5.48 to-2.35,tranquilizing method), improving the total effect rate(relative risk(RR), 1.26; 95% CI, 1.08 to 1.46,eliminating method) and reducing the TCM symptoms scores(MD,-2.24; 95% CI,-4.25 to-0.23,tranquilizing method) with a lower incidence of adverse events(RR, 0.46; 95% CI, 0.25 to 0.85, tonifying method). CHMs demonstrated benefits in lowering the score of Hamilton Anxiety Rating scale(MD,-6.77; 95% CI,-8.16 to-5.37, tonifying method),lowering the score of SAS(MD,-10.1;95% CI,-13.73 to-6.30, tonifying method) and reducing the TCM symptoms scores(MD,-2.18;95% CI,-3.12 to-1.24, tranquilizing method).CONCLUSION: We got a low evidence that CHMs,which had less side effects, showed potentially benefits to patients with CHD complicated with anxiety. While the results should be interpreted with caution. Trails with higher quality are required to verify the effectiveness and safety of CHMs for CHD complicated with anxiety.

Key words: Coronary disease, Anxiety, Drugs,Chinese herbal, Review, Randomized controlled trial