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Journal of Traditional Chinese Medicine ›› 2013, Vol. 33 ›› Issue (04): 439-443.DOI: 10.1016/s0254-6272(13)60145-4

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Fuzhengpaidu granule regulates immune activation molecules CD38 and human leukocyte antigen-D related on CD4+ and CD8+ T cells in patients with acquired immunodeficiency syndrome/human immunodeficiency virus

Feng Jiang, Rongxin Zhang, Zhenfang Gu, Huailing Zhang, Huijun Guo, Xin Deng, Jian Liang   

  1. AIDS Research Center, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine;Clinical Research Center, First Affiliated Hospital of Henan University of TCM;
  • Accepted:2013-08-15 Online:2013-08-15 Published:2013-08-15

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Abstract: OBJECTIVE: To evaluate the effect of Fuzhengpaidu granule (FZPDG) on immune activation molecules CD38 and human leukocyte antigen-D related (HLA-DR) on CD4+ and CD8+ cells in HIV/AIDS patients, and to explore the underlying mechanism of this therapy. METHODS: Plasma changes in CD3+, CD4+, CD8+, CD3+CD4+CD38+, CD3+CD4+HLA-DR+, CD3+ CD8+CD38+, and CD3+CD8+HLA-DR+levels in HIV/ AIDS patients treated with FZPDG for six months were examined by flow cytometry and compared with levels in healthy controls. RESULTS: The clinical trial included 34 outpatients with HIV/AIDS. Before treatment, plasma levels of CD38+ and HLA-DR+ on CD4/CD8 cells were higherthan those in 28 health controls (P0.05). Plasma levels of CD3+ CD4+CD38+and CD3+CD4+HLA-DR+were 2.3%± 2.2% and 7.8%±5.5% before treatment and 1.2%± 0.8% and 2.6%±1.0% after treatment, respectively. Plasma levels of CD3+CD8+CD38+ and CD3+CD8+ HLA-DR+ were 41.4%±13.4% and 17.8%±11.3% beforetreatment,whichchangedto27.1%±10.2%and 3.8%±2.4%aftertreatment,respectively(P

Key words: HIV, Acquired immunodeficiency syndrome, Fuzhengpaidu granule, Activated-leukocyte cell adhesion molecule, HLA-DR antigens, Immunocompetence

Cite this article

Feng Jiang, Rongxin Zhang, Zhenfang Gu, Huailing Zhang, Huijun Guo, Xin Deng, Jian Liang. Fuzhengpaidu granule regulates immune activation molecules CD38 and human leukocyte antigen-D related on CD4+ and CD8+ T cells in patients with acquired immunodeficiency syndrome/human immunodeficiency virus[J]. Journal of Traditional Chinese Medicine, 2013, 33(04): 439-443.