Abstract: OBJECTIVE:To explore the effect of antithymocyte globulin(ATG)/antilymphocyte globulin(ALG) plus kidney-nourishing Chinese medicinal(KNCM) on severe aplastic anemia(SAA).METHODS:Twenty-five subjects of severe aplastic anemia were treated with ATG/ALD plus KNCM between 1992 and 2009,and the clinical data before and after treatment were collected and analyzed.RESULTS:Of the 25 patients,9 were nearly cured,6 were improved,5 were in remission,and 5 failed.The overall effective rate was 80.0%.The 3-year,5-year,10-year,15-year survival rate were respectively 98.6%,97.3%,97.3%,67.5%,and median survival time was 180 months.Compared to the conditions before administering the medication of ATG/ALG plus KNCM,after 2 weeks,reticulocyte was first improved(P=0.001);one month later,followed by palette(P=0.037);two months later,by neutrophil cell in peripheral blood(P=0.001);three months later,then by the hemoglobin(P=0.012).By conducting 1-year follow-up,1 case of complication-paroxysmal nocturnal hemoglobinuria(PNH) was identified and the patient still alive today.CONCLUSION:ATG/ALG plus KNCM had better effect on SAA and could improve patients' survival rate.

Key words: Anemia,aplastic, Reinforcing kidney, Drugs,Chinese herbal, Antilymphocyte serum, Antithymocyte serum