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Journal of Traditional Chinese Medicine ›› 2012, Vol. 32 ›› Issue (03): 437-441.DOI: 10.1016/s0254-6272(13)60051-5

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Anti-inflammatory and analgesic effects of Yaotuitong Capsules in experimental rats with chemically induced radicular neuritis

Xing, Qingchang; Huang, Zhenjun; Zhang, Jianfu   

  1. 309 Hosp Chinese PLA, Dept Orthoped, Beijing 100091, Peoples R China; Tradit Chinese Med Univ Henan Prov, Dept Orthoped, Zhengzhou 450000, Peoples R China
  • Accepted:2012-09-15 Online:2012-09-15 Published:2012-09-15

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Abstract: OBJECTIVE:The aims of this study were to determine the anti-inflammatory and analgesic effects of Yaotuitong(translation:low back and leg pain) capsules,a Chinese herbal preparation,and the histological changes it induces in experimental rats with chemically induced radicular neuritis.METHODS:Wistar rats were randomly divided into normal,model,Western medicine,and traditional Chinese medicine groups(n=24 per group).We surgically duplicated a chemical radicular neuritis model to simulate lumbar intervertebral disc protrusion.Granuloma formation was measured on postoperative days(PODs) 3,7,14,and 21.Prostaglandin E 2 and 5-hydroxytryptamine(inflammation mediators) levels in the surrounding tissue and the histology of the nerve root were determined on PODs 7 and 14.RESULTS:Yaotuitong capsules significantly reduced prostaglandin E 2(P

Key words: Yaotuitong capsules, Radiculitis, Inflammation mediators

Cite this article

Xing, Qingchang; Huang, Zhenjun; Zhang, Jianfu. Anti-inflammatory and analgesic effects of Yaotuitong Capsules in experimental rats with chemically induced radicular neuritis[J]. Journal of Traditional Chinese Medicine, 2012, 32(03): 437-441.