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Journal of Traditional Chinese Medicine ›› 2012, Vol. 32 ›› Issue (02): 278-282.DOI: 10.1016/s0254-6272(13)60025-4

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Relationship between urinary nephrin and urinary albumin changes in diabetic rats and effects of Yiqiyangyinhuayutongluo Recipe

Li Li Li , Chen Zhi Qiang , Wang Yue Hua , Zhang Jiang Hua , Yin Zhi Wei , Li Lin Lin , Zhang Xue Yun , Wang Feng Li   

  1. Institute of Integration of Traditional Chinese Medicine-Western Medicine,Hebei Medical University;Traditional Chinese Medicine Hospital of Hebei Province;
  • Accepted:2012-06-15 Online:2012-06-15 Published:2012-06-15

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Abstract: OBJECTIVE:To investigate the dynamic changes of urinary nephrin,and the relationship between it and urinary albumin excretion rate(UAER) in a diabetic rat model,as well the effects of yiqiyangyinhuayutongluo recipe.METHODS:Diabetic model was induced by high fat diet combined with low-dose Streptozotocin(STZ) in rats.Normal group(NG),model group(MG),and yiqiyangyinhuayutongluo recipe treated group(YHTG) were set.Gastrointestinal Yiqiyangyinhuayutongluo recipe was administered once daily for 32 w.At the end of the 2nd w(2w),8w,16w,and 32w,fasting blood glucose(FBG),UAER and 24h urinary nephrin(U-nephrin) were detected.RESULTS:Compared with NG,FBG in MG increased notably(P0.9,and P

Key words: Yiqiyangyinhuayutongluo recipe, Diabetic nephropathy, Urinary nephrin, Urinary albumin excretion rate, SD rats

Cite this article

Li Li Li , Chen Zhi Qiang , Wang Yue Hua , Zhang Jiang Hua , Yin Zhi Wei , Li Lin Lin , Zhang Xue Yun , Wang Feng Li. Relationship between urinary nephrin and urinary albumin changes in diabetic rats and effects of Yiqiyangyinhuayutongluo Recipe[J]. Journal of Traditional Chinese Medicine, 2012, 32(02): 278-282.