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Journal of Traditional Chinese Medicine ›› 2014, Vol. 34 ›› Issue (01): 23-29.DOI: 10.1016/S0254-6272(14)60049-2

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Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway

Jinhuan Wang, Feng Sun, Weizheng Sun, Yanli Yong, Haitao Shi, Sijia Liu, Limei Liu   

  1. Department of Hematology,First Affiliated Hospital,Heilongjiang University of Chinese Medicine;Department of Traditional Chinese Medicine,Longnan Hospital of Daqing City;Department of Encephalopathy,Chinese Medicine Hospital of Harbin;Renal Department of Internal Medicine,Heilongjiang Provincial Academy of Traditional Chinese Medicine;
  • Accepted:2014-02-15 Online:2014-02-15 Published:2022-04-05

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Abstract: OBJECTIVE:To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia(NSAA)and investigate its effect on the mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)pathway.METHODS:Sixty NSAA patients were divided equally into two groups.Subjects in the experimental group were treated with Busuishengxue granules,and the control group with Zaizaoshengxue tablets.The treatment course was 6 months and cu-rative efficacy was compared between the two groups as well as with 10 healthy individuals.Flow cytometry(FCM)was used to detect the intracellular concentration of Ca2+([Ca2+]i).Western blotting was employed to detect the expression of enzymes in the MAPK/ERK pathway.RESULTS:The efficacy of Busuishengxue granules was significantly better than that of Zaizaoshengxue tablets(P

Key words: Anemia,aplastic, MAP kinase signaling system, Busuishengxue granule, Zaizaoshengxue tablet

Cite this article

Jinhuan Wang, Feng Sun, Weizheng Sun, Yanli Yong, Haitao Shi, Sijia Liu, Limei Liu. Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway[J]. Journal of Traditional Chinese Medicine, 2014, 34(01): 23-29.