Advanced Search

Journal of Traditional Chinese Medicine ›› 2020, Vol. 40 ›› Issue (5): 749-757.DOI: 10.19852/j.cnki.jtcm.2020.05.004

Previous Articles     Next Articles

Effectiveness of Huachansu injection combined with chemotherapy for treatment of gastric cancer in China: a systematic review and Meta-analysis

Wu Jiarui, Zhang Dan, Ni Mengwei, Xue Jiaping, Wang Kaihuan, Duan Xiaojiao, Liu Shuyu   

  1. Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine;
  • Online:2020-10-15 Published:2020-10-15
  • Supported by:
    Supported by the National Natural Science Foundation of China Study on Key Influencing Factors of Allergic Reaction Induced by Chinese Herbal Injection Based on Three-Dimensional Database and Multidimensional Data Mining (No.81473547), Construction of Multi-Dimensional Clinical Evaluation Model of Salvia Miltiorrhiza Injection in the Treatment of Unstable Angina Pectoris Based on Bayesian Network Meta-Analysis (No. 81673829), Young Scientists Training Program of Beijing University of Chinese Medicine

PDF

707

Abstract: OBJECTIVE: to evaluate the effectiveness and safety of Huachansu(HCS) injection plus chemotherapy in the treatment of gastric cancer.METHODS: A thorough and systematic retrieval of randomized controlled trials(RCTs) concerning HCS injection for treating gastric cancer was conducted in several electronic databases from inception to May 10, 2018. The quality of the RCTs was assessed by the Cochrane risk of bias tool. And the data about objective remission rate, performance status, adverse drug reactions(ADRs) and other outcomes were extracted and analyzed by Review Manager 5.3 and Stata 13.0 software.RESULTS: A total of 14 RCTs with 976 participants were involved in the current Meta-analysis. The results suggested that HCS injection combined with chemotherapy was associated with better effects than receiving conventional chemotherapy alone in respect of improving the objective response rate[RR = 1.18, 95% CI(1.03, 1.37), Z = 2.32, P = 0.02],and performance status [RR = 1.84,95% CI(1.43,2.36), Z = 4.74, P < 0.000 01]. In addition, HCS injection combined with chemotherapy could relieve pain for patients with gastric cancer.CONCLUSION: This Meta-analysis revealed that HCS injection plus chemotherapy might more effective than chemotherapy in treating gastric cancer.Nevertheless, more large-scale and rigorously designed RCTs should be performed to validate this finding.

Key words: Stomach neoplasms, Drug therapy, Randomized controlled trial, Meta-analysis, Huachansu injection

Cite this article

Wu Jiarui, Zhang Dan, Ni Mengwei, Xue Jiaping, Wang Kaihuan, Duan Xiaojiao, Liu Shuyu. Effectiveness of Huachansu injection combined with chemotherapy for treatment of gastric cancer in China: a systematic review and Meta-analysis[J]. Journal of Traditional Chinese Medicine, 2020, 40(5): 749-757.